New humanized mouse model provides insight into immunotherapy resistance

Scientists at The Wistar Institute have created an advanced humanized immune system mouse model that allows them to examine resistance to immune checkpoint blockade therapies in melanoma. It has revealed a central role for mast cells. These findings were published today in the journal Nature Communications. Checkpoint inhibitors revolutionized therapeutic options for advanced melanoma. However, […]

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Marriott, BlueCross suspend donations to U.S. lawmakers who voted against Biden certification

Marriott International Inc, the world’s largest hotel company, and the Blue Cross Blue Shield Association (BCBSA) said Sunday they will suspend donations to U.S. lawmakers who voted last week against certifying President-elect Joe Biden’s victory. “We have taken the destructive events at the Capitol to undermine a legitimate and fair election into consideration and will […]

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“Worried about free speech, FBI never issued intelligence bulletin about possible Capitol violence

WASHINGTON — FBI intelligence analysts gathered information about possible violence involving the U.S. Capitol on Jan. 6., but the FBI never distributed a formal intelligence bulletin, in part because of concerns that doing so might have run afoul of free speech protections, a current and two former senior FBI officials familiar with the matter told […]

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Ohio law requiring fetal remains to be buried or cremated draws praise, rebuke

A new Ohio law will force women who have surgical abortions to choose between cremating or burying fetal remains, sharpening the state’s definition of “humane” disposal. The decision, which goes into effect no later than April, has been criticized by abortion rights advocates and praised by pro-life supporters. “The law is about shaming and stigmatizing […]

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